Efficacy and safety of intravenously applied caffeine augmentation in electroconvulsive therapy
14-11-2025Electroconvulsive therapy (ECT) is a neuromodulation procedure that uses short electrical pulses causing a brief generalized seizure to treat depression, mania, schizophrenia, and catatonia. Achieving sufficient seizure length is crucial for maintaining therapeutic efficacy, as it influences treatment response. However, over successive sessions, seizure length becomes shorter requiring an increased energy set to generate a sufficient seizure, potentially causing more side effects. Caffeine...
14-11-2025Electroconvulsive therapy (ECT) is a neuromodulation procedure that uses short electrical pulses causing a brief generalized seizure to treat depression, mania, schizophrenia, and catatonia. Achieving sufficient seizure length is crucial for maintaining therapeutic efficacy, as it influences treatment response. However, over successive sessions, seizure length becomes shorter requiring an increased energy set to generate a sufficient seizure, potentially causing more side effects. Caffeine...
Acute effects of midwakh smoking on plasma nicotine levels and cardiopulmonary function
14-11-2025CONCLUSION: This study involving a small sample demonstrates changes in blood nicotine and cotinine levels and differences in cardiopulmonary function among midwakh smokers; however, findings should be interpreted with caution due to limited generalizability.
14-11-2025CONCLUSION: This study involving a small sample demonstrates changes in blood nicotine and cotinine levels and differences in cardiopulmonary function among midwakh smokers; however, findings should be interpreted with caution due to limited generalizability.
Utility of bronchoalveolar lavage in checkpoint inhibitor pneumonitis evaluation: a narrative review
14-11-2025CONCLUSIONS: In current clinical practice, BAL remains an important investigation to support a diagnosis of CIP; however, its diagnostic value remains uncertain. Enhanced understanding of the CIP immune landscape is fundamental to identifying robust diagnostic and predictive biomarkers that could improve diagnosis and patient outcomes in cancer patients treated with checkpoint inhibitors.
14-11-2025CONCLUSIONS: In current clinical practice, BAL remains an important investigation to support a diagnosis of CIP; however, its diagnostic value remains uncertain. Enhanced understanding of the CIP immune landscape is fundamental to identifying robust diagnostic and predictive biomarkers that could improve diagnosis and patient outcomes in cancer patients treated with checkpoint inhibitors.
SegDecon bridges histology and transcriptomics through AI-based nuclei segmentation and image-informed spatial deconvolution
14-11-2025Precise spatial mapping of cellular composition is a central goal in spatial transcriptomics (ST), yet current methods often assume uniform or manually estimated cell counts across spatial spots, potentially distorting biological interpretation. Here, we present SegDecon, a computational framework that integrates image-derived cell count estimation into Bayesian deconvolution. SegDecon enhances nuclei segmentation using Hue-Saturation-Value (HSV) color space transformation, morphological...
14-11-2025Precise spatial mapping of cellular composition is a central goal in spatial transcriptomics (ST), yet current methods often assume uniform or manually estimated cell counts across spatial spots, potentially distorting biological interpretation. Here, we present SegDecon, a computational framework that integrates image-derived cell count estimation into Bayesian deconvolution. SegDecon enhances nuclei segmentation using Hue-Saturation-Value (HSV) color space transformation, morphological...
Knowledge and attitudes about epilepsy of neurology outpatients in Türkiye
14-11-2025CONCLUSION: This study focused on a subgroup of adults without epilepsy who had other neurological conditions. The findings may illuminate the critical role of education and public awareness in fostering more positive attitudes toward individuals with epilepsy, reducing stigma, and facilitating their social integration.
14-11-2025CONCLUSION: This study focused on a subgroup of adults without epilepsy who had other neurological conditions. The findings may illuminate the critical role of education and public awareness in fostering more positive attitudes toward individuals with epilepsy, reducing stigma, and facilitating their social integration.
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Illness perception in patients with D.M. type II in Cambodia
This research is a qualitative study of illness perception in patients registered in a clinic in a rural area in Cambodia (Cambodia-Dutch Organization). All patients in the clinic with Diabetes...
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