Cardiovascular Disease Science

The Network of Exosomes miRNA and p-MLC2 Regulatory Pathway Induced Pathological Cardiac Hypertrophy in Vasn Deficient Mice
14-11-2025Pathological cardiac hypertrophy was an important inducement of heart failure, cardiac arrest, and other diseases. To explore how Vasn knockout induced pathological cardiac hypertrophy, bioinformatics and functional studies illustrated the possible mechanism by clarifying the influence of exosome miRNA on the p-MLC2 signal pathway. B-ultrasound, electrocardiogram, pathological staining, and Q-PCR were used to clarify the changes in typical imaging indexes, pathological indexes, and marker...

Extreme Heat and Emergency Department Presentations for Circulatory and Respiratory Conditions: A 5-Year Study in Two Large Hospitals in Australia
14-11-2025In Australia, heatwaves result in more fatalities than any other natural disaster, underscoring their significant public health impact. Heatwaves have been associated with heightened ambulance demand, and this study examines their relationship with emergency department (ED) presentations for circulatory and respiratory diseases. The analysis, focusing on the peak heatwave months of December and January over five years, revealed a positive correlation between maximum temperatures and ED...

Cardiovascular morbidity following epilepsy: A nationwide retrospective cohort study in South Korea
14-11-2025OBJECTIVE: This study evaluated the long-term risk of major cardiovascular diseases (CVDs) in patients with epilepsy using a nationwide cohort, aiming to address critical gaps in population-based evidence on brain-heart interactions.

Impact of diabetes on the effects of SGLT2 inhibitors on kidney outcomes: An updated drug/dose-dependent meta-analysis
14-11-2025CONCLUSION: SGLT2 inhibitors confer renal protection in both diabetic and non-diabetic populations, supporting their use in CKD management across a broad spectrum of patients. However, careful drug selection is warranted in diabetic patients at risk for DKA.

Comprehensive Analysis of the PANoptosis-Related Genes in Stroke Based on Single-Cell RNA-Seq and Spatial Transcriptomics
14-11-2025CONCLUSIONS: TNFRSF1A acts as a key PANoptosis-related biomarker and suggests microglial subclusters as therapeutic targets in ischemic stroke.