Obesity Science

Aggressive course of ectopic ACTH syndrome due to adrenal medulla hyperplasia. Case report
14-11-2025The article presents a description of a clinical case of an ectopic focus of adrenocorticotropic hormone (ACTH) hypersecretion located in the adrenal medulla in a 64-year-old obese woman without other characteristic clinical signs of hypercorticism, with complaints of rapidly progressing lower limb edema, severe muscle weakness, loss of appetite, weight loss by 4 kg, as well as stage 2 arterial hypertension and type 2 diabetes mellitus. The patient's blood biochemistry showed severe hypokalemia,...

Frequency of hypogonadism and clinical features of systemic sclerosis and idiopathic inflammatory myopathies in men depending on testosterone levels
14-11-2025CONCLUSION: A high frequency of hypogonadism was shown in men with SSc and IIМ. Reduced testosterone levels were accompanied by some metabolic disorders, as well as a high frequency of antibodies and clinical features characteristic of a more unfavorable course of the disease.

Visceral obesity as a risk factor for breast cancer
14-11-2025CONCLUSION: The results of the study emphasize the importance of VO and insulin resistance in the pathogenesis of breast cancer, which is important for early diagnosis and prevention of the disease.

The perspectives in obesity and type 2 diabetes therapy: the present and future of incretin therapy
14-11-2025The rates of increase in the incidence of type 2 diabetes mellitus (T2DM) and obesity in the world are steadily increasing and exceed even the wildest forecasts, which forces specialists to seek, develop and implement more effective therapeutic methods for these two interrelated non-communicable pandemics. This article discusses promising areas in the pharmacotherapy of obesity and T2DM with an emphasis on the development of a class of incretin hormone receptor agonists. Monoagonists...

Dyslipidemia in asthma: Treatable trait, or just a common comorbidity?
14-11-2025Asthma is a diverse disease that can be categorized into various phenotypes and endotypes, including obesity-re-lated asthma and allergic asthma. "Treatable traits (TTs)" represent a new approach to managing asthma. Asthma accompanied by dyslipidemia would be a distinct asthma phenotype that is becoming increasingly common. Therefore, dyslipidemia can potentially serve as a target for the management of asthma. Nevertheless, it remains highly under-researched compared to other observable traits....