Diabetes Mellitus Wetenschap

Polygenic subtype identified in ACCORD trial displays a favorable type 2 diabetes phenotype in the UKBiobank population
22-06-2024CONCLUSION: We have confirmed C4 individuals are a lower risk subpopulation of patients with T2D.

Exploratory risk prediction of type II diabetes with isolation forests and novel biomarkers
22-06-2024Type II diabetes mellitus (T2DM) is a rising global health burden due to its rapidly increasing prevalence worldwide, and can result in serious complications. Therefore, it is of utmost importance to identify individuals at risk as early as possible to avoid long-term T2DM complications. In this study, we developed an interpretable machine learning model leveraging baseline levels of biomarkers of oxidative stress (OS), inflammation, and mitochondrial dysfunction (MD) for identifying individuals...

HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes
22-06-2024HNF4A and HNF1A encode transcription factors that are important for the development and function of the pancreas and liver. Mutations in both genes have been directly linked to Maturity Onset Diabetes of the Young (MODY) and type 2 diabetes (T2D) risk. To better define the pleiotropic gene regulatory roles of HNF4A and HNF1A, we generated a comprehensive genome-wide map of their binding targets in pancreatic and hepatic cells using ChIP-Seq. HNF4A was found to bind and regulate known (ACY3,...

Adverse effects with semaglutide: a protocol for a systematic review with meta-analysis and trial sequential analysis
22-06-2024INTRODUCTION: Semaglutide is increasingly used for the treatment of type 2 diabetes mellitus, overweight and other conditions. It is well known that semaglutide lowers blood glucose levels and leads to significant weight loss. Still, a systematic review has yet to investigate the adverse effects with semaglutide for all patient groups.

Correlation between islet alpha cell function and peripheral neuropathy in patients with type 2 diabetes mellitus
22-06-2024CONCLUSION: Gluca30min may be a potentially valuable independent predictor for the occurrence of DPN.

Projecten

Koken met eigen kinderen - Dieet op de kaart
Het buurtcentrum Morschwijck draait al enige tijd een kookclub voor kinderen en een kookclub voor mensen met een verstandelijke beperking. In samenwerking met Cello zal er een kookclub worden gestart...
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Lekker goedkoop koken - Dieet op de kaart
Het project van kerken en andere partners met en voor mensen die door de crisis geraakt zijn en door financiële problemen  geen goede voeding...
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Ziekteperceptie bij patiënten met D.M. type II in Cambodja
Deze studie betreft een kwalitatief onderzoek naar ziekteperceptie bij patienten die geregistreerd zijn in een kliniek in een dunbevolkte omgeving in Cambodja (Cambodia-Dutch Organization). Alle...
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