Programmed cell death in the cognitive impairment of obstructive sleep apnea
20-06-2025Cognitive impairment (CI) is a significant and extraordinary complication of obstructive sleep apnea (OSA) patients. Programmed cell death (PCD) is an active and ordered process regulated by genes. A growing number of studies find that PCD is responsible for cognitive dysfunction and plays an important role in various neurological diseases, which involve apoptosis, necroptosis, pyroptosis, ferroptosis, and cell death associated with autophagy. However, the influence of PCD on OSA-CI remains...
20-06-2025Cognitive impairment (CI) is a significant and extraordinary complication of obstructive sleep apnea (OSA) patients. Programmed cell death (PCD) is an active and ordered process regulated by genes. A growing number of studies find that PCD is responsible for cognitive dysfunction and plays an important role in various neurological diseases, which involve apoptosis, necroptosis, pyroptosis, ferroptosis, and cell death associated with autophagy. However, the influence of PCD on OSA-CI remains...
Sleep disorders and Alzheimer's disease: relationship and mechanisms involving neuroinflammation, orexin and Abeta
20-06-2025CONCLUSION: SSD in AD is associated with significant cognitive impairment, neuroinflammation, orexin elevation and Aβ deposition. Hippocampal astroglial activation, hypothalamic orexin elevation and sleep architecture disturbance precede Aβ deposition in hippocampus and cognitive impairment in 5XFAD mice.
20-06-2025CONCLUSION: SSD in AD is associated with significant cognitive impairment, neuroinflammation, orexin elevation and Aβ deposition. Hippocampal astroglial activation, hypothalamic orexin elevation and sleep architecture disturbance precede Aβ deposition in hippocampus and cognitive impairment in 5XFAD mice.
Using DISE to characterize upper airway collapse and ventilatory characteristics in modeling obstructive sleep apnea
20-06-2025CONCLUSION: Incorporating quantitative ventilatory measures into DISE provides valuable insights into individualized patterns of airway collapsibility and OSA pathophysiology. This could allow for more targeted approaches to further research and eventually improve management of the disorder.
20-06-2025CONCLUSION: Incorporating quantitative ventilatory measures into DISE provides valuable insights into individualized patterns of airway collapsibility and OSA pathophysiology. This could allow for more targeted approaches to further research and eventually improve management of the disorder.
A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases
20-06-2025Human diseases are characterized by intricate cellular dynamics. Single-cell transcriptomics provides critical insights, yet a persistent gap remains in computational tools for detailed disease progression analysis and targeted in silico drug interventions. Here we introduce UNAGI, a deep generative neural network tailored to analyse time-series single-cell transcriptomic data. This tool captures the complex cellular dynamics underlying disease progression, enhancing drug perturbation modelling...
20-06-2025Human diseases are characterized by intricate cellular dynamics. Single-cell transcriptomics provides critical insights, yet a persistent gap remains in computational tools for detailed disease progression analysis and targeted in silico drug interventions. Here we introduce UNAGI, a deep generative neural network tailored to analyse time-series single-cell transcriptomic data. This tool captures the complex cellular dynamics underlying disease progression, enhancing drug perturbation modelling...
Liver fibrosis evaluation in patients with psychiatric diseases
20-06-2025CONCLUSION: Psychiatric patients are at risk of liver fibrosis and steatosis. Systematic screening for liver diseases should be required. Further studies are needed to determine the best strategies for prevention and treatment.
20-06-2025CONCLUSION: Psychiatric patients are at risk of liver fibrosis and steatosis. Systematic screening for liver diseases should be required. Further studies are needed to determine the best strategies for prevention and treatment.
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Illness perception in patients with D.M. type II in Cambodia
This research is a qualitative study of illness perception in patients registered in a clinic in a rural area in Cambodia (Cambodia-Dutch Organization). All patients in the clinic with Diabetes...
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