Diabetes Mellitus Science

Global prescription patterns and practices: Utilization of statins in diabetes management across nations
09-07-2025Cardiovascular disease (CVD) poses a significant risk for individuals with type 2 diabetes mellitus (T2DM), and statins are integral in preventing such complications. However, global statin prescription practices often diverge from clinical guidelines, which can lead to suboptimal cardiovascular outcomes. This review examines global trends in statin prescription patterns in T2DM management, focusing on adherence to clinical guidelines, gaps in statin utilization, and the impact on cardiovascular...

Exploring the Side Effects of GLP-1 Receptor Agonist: To Ensure Its Optimal Positioning
09-07-2025Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated considerable efficacy in the treatment of diabetes and obesity, it is essential to recognize that their use is associated with certain intrinsic risks that must not be disregarded. The incidence of adverse effects, particularly gastrointestinal complications, psychiatric disorders, and ocular problems, highlights the critical need for thorough patient assessment and continuous monitoring to ensure both the safety...

Semaglutide Therapy and Accelerated Sarcopenia in Older Adults with Type 2 Diabetes: A 24-Month Retrospective Cohort Study
09-07-2025CONCLUSION: The use of Semaglutide is associated with muscle loss and functional decline in older adults with type 2 diabetes, particularly at higher doses. This effect is especially significant in patients with sarcopenia. Consequently, it is crucial to assess the risks and benefits for each elderly patient individually and to implement appropriate monitoring and interventions. The potential for nutritional supplementation and targeted exercise regimens to counteract semaglutide-associated...

Associations of Leukocyte-Derived Chemotaxin-2 (LECT2) with Insulin Resistance and Metabolic Syndrome in Type 2 Diabetes: A Cross-Sectional Study
09-07-2025CONCLUSION: LECT2 concentrations were elevated in T2D patients combined with MetS and were significantly related to IR. These results indicate that LECT2 could contribute to the pathogenesis of T2D accompanied by MetS, and LECT2 may represent a promising therapeutic target for MetS and its related metabolic disturbances.

Potential Causal Relationship Between Chronic Obstructive Pulmonary Disease and Diabetes: A Bidirectional Two-Sample Mendelian Randomization Study
09-07-2025CONCLUSION: This study suggested a modest but statistically significant causal association between T2D and COPD in individuals of European ancestry. Further explorations are required to better understand the underlying mechanisms linking diabetes to COPD development.