COPD Science

Mesenchymal stem cell-derived exosomes-a promising therapeutic approach to improve neurocognitive disorders in chronic obstructive pulmonary disease
20-06-2025Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and is often accompanied by neurocognitive disorders. It seriously affects the quality of life and treatment outcome of patients. COPD-induced neurocognitive disorders (COPD-NCDs) are driven by systemic inflammation, blood-brain barrier (BBB) disruption, and chronic hypoxia, but there is currently no effective treatment to prevent or reverse cognitive decline. Mesenchymal stem cell-derived...

Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections
20-06-2025Periodontitis is a chronic inflammatory disease initiated by plaque microorganisms, with the regulatory mechanisms of its progression being a primary research focus. Ferroptosis, a unique form of cell death driven by iron-dependent lipid peroxidation, has been increasingly recognized for its crucial role in modulating chronic inflammation. This study focused on the molecular mechanisms by which plaque microorganisms and the inflammatory microenvironment trigger ferroptosis in periodontal cells,...

Estimating Global Antibiotic Needs for Chronic Obstructive Pulmonary Disease and Community- and Hospital- acquired Pneumonia in 20 Countries: A Modelling Analysis
20-06-2025CONCLUSIONS: Prudent antibiotic use is essential to curb antimicrobial resistance. This framework offers a method for estimating needs and informing global planning.

PM(2.5) as a risk factor for sleep oxygen desaturation in COPD: identifying susceptible individuals by smoking and inflammatory phenotypes
20-06-2025CONCLUSIONS: Airborne PM(2.5) is an important risk factor for sleep hypoxia in patients with COPD, especially for individuals with smoking history and specific inflammatory phenotypes.

Chronic obstructive pulmonary disease is a risk factor for non-tuberculous mycobacterial pulmonary disease: a population-based matched cohort study
20-06-2025CONCLUSIONS: Individuals with COPD had approximately a twofold increased risk of developing NTM-PD compared with matched controls. Being underweight and having bronchiectasis were identified as risk factors for developing NTM-PD.