Asthma Adults Science
Chronic Lung Diseases and Depressive Symptoms in Older Adults: Insights from Observational Studies and Mendelian Randomization
20-06-2025CONCLUSION: Depressive symptoms are associated with an increased risk of CLDs, reduced BADL promote the risk of CLDs in older adults with depressive symptoms, but the underlying pathological mechanism still needs to be clarified in future research.
20-06-2025CONCLUSION: Depressive symptoms are associated with an increased risk of CLDs, reduced BADL promote the risk of CLDs in older adults with depressive symptoms, but the underlying pathological mechanism still needs to be clarified in future research.
Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Dupilumab on Pre-Bronchodilator Forced Expiratory Volume in 1 Second (FEV(1)) in Uncontrolled Moderate-To-Severe Asthma
19-06-2025In this study, we investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationship of dupilumab as an add-on therapy in the intent-to-treat (ITT) uncontrolled moderate-to-severe asthma population and identified the factors significantly contributing to variability in forced expiratory volume in 1 second; (FEV(1)). A semi-mechanistic population PK/PD model was developed using data from two placebo-controlled pivotal studies in 2654 adult and adolescent patients (n = 794 treated with placebo;...
19-06-2025In this study, we investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationship of dupilumab as an add-on therapy in the intent-to-treat (ITT) uncontrolled moderate-to-severe asthma population and identified the factors significantly contributing to variability in forced expiratory volume in 1 second; (FEV(1)). A semi-mechanistic population PK/PD model was developed using data from two placebo-controlled pivotal studies in 2654 adult and adolescent patients (n = 794 treated with placebo;...
Assessment of ventilation heterogeneity in severe asthma using phase-resolved functional lung magnetic resonance imaging
19-06-2025Ventilation heterogeneity is a hallmark of asthma. This study examines the feasibility of phase-resolved functional lung magnetic resonance imaging (PREFUL MRI) in the evaluation of ventilation heterogeneity in severe asthma, its response to bronchodilator, and correlation with spirometry. Twenty-three patients with severe asthma and seven healthy volunteers completed PREFUL MRI and spirometry pre and post-bronchodilator. Ventilation heterogeneity was assessed using ventilation defect...
19-06-2025Ventilation heterogeneity is a hallmark of asthma. This study examines the feasibility of phase-resolved functional lung magnetic resonance imaging (PREFUL MRI) in the evaluation of ventilation heterogeneity in severe asthma, its response to bronchodilator, and correlation with spirometry. Twenty-three patients with severe asthma and seven healthy volunteers completed PREFUL MRI and spirometry pre and post-bronchodilator. Ventilation heterogeneity was assessed using ventilation defect...
Diagnostic Use of CCR3, CD63, CD203c and FcepsilonRIalpha on Blood Leukocytes of Allergic Asthma and Combined Allergic Rhinitis and Asthma Syndrome
19-06-2025Altered basophil identification markers have been discovered to associate with allergic asthma (AA) recently. However, little is known of the expressions of basophil markers in blood granulocytes. We therefore parallel tested them in peripheral blood mononuclear cell (PBMC) and granulocyte populations of patients with AA and combined allergic rhinitis and asthma (ARA) by flow cytometry and assessed their diagnostic performance and examined plasma levels of EDN, LTC(4) and PGD(2). We found...
19-06-2025Altered basophil identification markers have been discovered to associate with allergic asthma (AA) recently. However, little is known of the expressions of basophil markers in blood granulocytes. We therefore parallel tested them in peripheral blood mononuclear cell (PBMC) and granulocyte populations of patients with AA and combined allergic rhinitis and asthma (ARA) by flow cytometry and assessed their diagnostic performance and examined plasma levels of EDN, LTC(4) and PGD(2). We found...
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Illness perception in patients with D.M. type II in Cambodia
This research is a qualitative study of illness perception in patients registered in a clinic in a rural area in Cambodia (Cambodia-Dutch Organization). All patients in the clinic with Diabetes...
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