Astma Volwassenen Wetenschap


Applying interpretable deep learning models to identify chronic cough patients using EHR data
15-09-2021CONCLUSIONS: By applying deep learning models, chronic cough patients can be reliably identified for prospective or retrospective research through medication and diagnosis data, widely available in EHR and electronic claims data, thus improving the generalizability of the patient identification algorithm. Deep learning models can identify chronic cough patients with even higher sensitivity and specificity when structured and unstructured EHR data are utilized. We anticipate language-based data...

The rescue intervention strategy for asthma patients under severe air pollution: a single-center prospective randomized controlled trial
15-09-2021Objective: The aim of our study is to provide a novel strategy to administer treatment at the first signs of severe air pollution and before patients experience symptoms for preventing airway damage.Methods: This single-center, prospective, randomized and standard treatment parallel control clinical trial recruited adult asthma patients. The patients were randomized into either the rescue intervention strategy (RIS) group or control group. The rescue intervention strategy for the RIS group...

Pharmacokinetics and Pharmacodynamics of Itepekimab in Healthy Adults and Patients With Asthma: Phase I First-in-Human and First-in-Patient Trials
15-09-2021Itepekimab is a monoclonal antibody that targets interleukin-33 and has been shown to reduce airway inflammation and associated tissue damage in preclinical studies. We assessed the safety, tolerability, pharmacokinetics, and pharmacodynamic profiles of single-ascending and multiple-ascending doses of itepekimab in 2 randomized, double-blind, placebo-controlled phase I studies. Healthy adults (N = 40) were randomized to the single-dose study and patients with moderate asthma (N = 23) to the...

Randomized study of rivaroxaban vs. placebo on disease progression and symptoms resolution in high-risk adults with mild COVID-19
15-09-2021CONCLUSIONS: Our study did not demonstrate an impact of rivaroxaban on disease progression in high-risk adults with mild COVID-19. There remains a critical public health gap in identifying scalable effective therapies for high-risk people in the outpatient setting to prevent COVID-19 progression.

Projecten

Koken met eigen kinderen - Dieet op de kaart
Het buurtcentrum Morschwijck draait al enige tijd een kookclub voor kinderen en een kookclub voor mensen met een verstandelijke beperking. In samenwerking met Cello zal er een kookclub worden gestart...
Lees meer

Lekker goedkoop koken - Dieet op de kaart
Het project van kerken en andere partners met en voor mensen die door de crisis geraakt zijn en door financiële problemen  geen goede voeding...
Lees meer

Ziekteperceptie bij patiƫnten met D.M. type II in Cambodja
Deze studie betreft een kwalitatief onderzoek naar ziekteperceptie bij patienten die geregistreerd zijn in een kliniek in een dunbevolkte omgeving in Cambodja (Cambodia-Dutch Organization). Alle...
Lees meer