Astma Kinderen Wetenschap

Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity.
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Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity.

Allergol Immunopathol (Madr). 2017 Jun 20;:

Authors: Fouda EM, Kamel TB, Nabih ES, Abdelazem AA

Abstract
BACKGROUND: In recent years, the prevalence of asthma has risen in developed countries, and its extent related to a change in our indigenous microbiota. Helicobacter pylori disappearance across the population represents a fundamental change in our human microbiota and has preceded the rise in asthma prevalence.
OBJECTIVE: To assess the relationship between childhood asthma and Helicobacter pylori infection.
METHODS: Quantitative determination of Helicobacter pylori IgG among 90 asthmatic children and 90 - age and gender - matched non-atopic, non-asthmatic healthy children was performed using ELISA in serum of all participants.
RESULTS: Helicobacter pylori IgG seropositivity was found in 25.6% of asthmatics compared to 44.4% of controls. Asthmatics showed lower median Helicobacter pylori IgG titre compared to healthy controls. We also detected a significant inverse relationship between Helicobacter pylori IgG titre and asthma severity.
CONCLUSION: Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity.

PMID: 28645881 [PubMed - as supplied by publisher]



Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients.
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Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients.

Allergol Immunopathol (Madr). 2017 Jun 20;:

Authors: Nacaroglu HT, Gayret OB, Erol M, Buke O, Zengi O, Tasdemir M, Tasdemir Z, Yigit O

Abstract
BACKGROUND: It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment.
OBJECTIVE: This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma and to identify the biomarkers that play a role in this inflammation.
METHODS: The study included patients aged 6-16 years who were diagnosed with asthma in the paediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey. Complete blood count parameters were compared between three groups: obese asthmatic (n=43), obese non-asthmatic (n=45), and non-obese non-asthmatic (control group, n=30). Levels of high-sensitive CRP (hs-CRP), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), and matrix metalloproteinase-9 (MMP-9), and 25(OH)-vitamin D were compared between the groups.
RESULTS: No statistically significant differences were observed in 25(OH)-vitamin D, NGAL, OPN, hs-CRP, and MMP-9 levels between groups. There was a statistically significant negative correlation between FEV1/FVC and NGAL and MMP-9.
CONCLUSION: This is the first study to investigate levels of hs-CRP, NGAL, OPN, MMP-9, and 25(OH)-vitamin D in obese asthmatic children. Larger studies with sputum and BAL examinations are required to determine the potential of biomarkers for identifying inflammation in obese asthmatic children.

PMID: 28645880 [PubMed - as supplied by publisher]



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