Astma Kinderen Wetenschap

Current-Smoking alters Gene Expression and DNA Methylation in the Nasal Epithelium of Asthmatics
14-05-2021Current-smoking contributes to worsened asthma prognosis, more severe symptoms and limits the beneficial effects of corticosteroids. As the nasal epithelium can reflect smoking-induced changes in the lower airways, it is a relevant source to investigate changes in gene expression and DNA methylation. This study explores gene expression and DNA methylation changes in current and ex-smokers with asthma. Matched gene expression and epigenome-wide DNA methylation samples collected from nasal...

Evaluating the Financial Sustainability of the School-Based Telemedicine Asthma Management Program
14-05-2021Using telemedicine to improve asthma management in underserved communities has been shown to be highly effective. However, program operating costs are perceived as the main barrier to dissemination and scaling up. This study evaluated whether a novel, evidence-based School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) program, designed to overcome barriers to care for families of urban school-aged children, can be financially sustainable in real-world urban school settings. Eligible...

Comparison of the effect of fluticasone combined with salmeterol and fluticasone alone in the treatment of pediatric asthma: review and meta-analysis
14-05-2021CONCLUSIONS: The efficacy of salmeterol + fluticasone is better than fluticasone alone, and the efficacy of salmeterol + fluticasone is equal to doubling the dose of fluticasone in the treatment of pediatric asthma.

Heterogeneity of emergency treatment practices in wheezing preschool children
14-05-2021CONCLUSION: ER treatment guidelines for preschool children with wheezing are poorly endorsed. Research is needed to identify approaches to guideline implementation that are specific for primary care. Clinical research should focus on strengthening recommendations that are currently not embraced. ER treatment protocols need to be updated and adherence to guidelines should be re-evaluated.

Ventilation heterogeneity in children with severe asthma
14-05-2021Small airway disease, characterised by ventilation heterogeneity (VH), is present in a subgroup of patients with asthma. Ventilation heterogeneity can be measured using multiple breath washout testing. Few studies have been reported in children. We studied the relationship between VH, asthma severity, and spirometry in a cross-sectional observational cohort study involving children with stable mild-moderate and severe asthma by GINA classification and a group of healthy controls. Thirty-seven...

Projecten

Koken met eigen kinderen - Dieet op de kaart
Het buurtcentrum Morschwijck draait al enige tijd een kookclub voor kinderen en een kookclub voor mensen met een verstandelijke beperking. In samenwerking met Cello zal er een kookclub worden gestart...
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Lekker goedkoop koken - Dieet op de kaart
Het project van kerken en andere partners met en voor mensen die door de crisis geraakt zijn en door financiële problemen  geen goede voeding...
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Ziekteperceptie bij patiƫnten met D.M. type II in Cambodja
Deze studie betreft een kwalitatief onderzoek naar ziekteperceptie bij patienten die geregistreerd zijn in een kliniek in een dunbevolkte omgeving in Cambodja (Cambodia-Dutch Organization). Alle...
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